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Cannabis and Your Endocannabinoid System…My What?

My Endocannabinoid, what…?

Updated 10/27/23

Besides being an impressive term to casually throw out at your next dinner party (insert feelings of genius), the endocannabinoid system (ECS) is a remarkable system within our bodies. This complex network of cell receptors and molecules helps regulate various physiological processes in the body, including mood, appetite, pain, and immune function.

The ECS is made up of three main parts: endocannabinoids, cannabinoid receptors, and metabolic enzymes and is responsible for maintaining balance within our bodies and ensuring that everything runs smoothly.

Cannabis and your ECS

Cannabis works with your endocannabinoid system by interacting with its receptors.

The two primary receptors in the endocannabinoid system are called CB1 and CB2 receptors. CB1 receptors are mainly found in the brain and central nervous system.

CB2 receptors are primarily found in the immune system and peripheral tissues.

When a person consumes cannabis, the active compounds in the plant, such as THC (tetrahydrocannabinol) and CBD (cannabidiol), interact with the CB1 and CB2 receptors in the body, producing a wide range of effects.

THC, the main psychoactive compound in cannabis, binds to CB1 receptors in the brain, leading to the feeling of euphoria associated with cannabis use. THC also affects other physiological processes, such as appetite and pain perception.

CBD, on the other hand, has a more complex interaction with the endocannabinoid system. It doesn’t bind directly to CB1 or CB2 receptors. Still, it can indirectly modulate their activity, leading to various therapeutic effects, such as reducing anxiety, inflammation, and seizures.

It’s exciting to know that ongoing research into cannabis and the endocannabinoid system will lead to new insights into how legal cannabis can be used to promote health and well-being. With each discovery, we gain a deeper understanding of the therapeutic potential of cannabis and how it can positively impact our bodies and minds.

In the meantime, throw the term “Endocannabinoid System” like the bad@$$, educated cannabis user you are.

“In the Weeds” with Dr. Ross F. Campensa, MD | What is the endocannabinoid system?
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